Crop Biotech Update


A weekly summary of world developments in agri-biotech for developing countries, produced by the Global Knowledge Center on Crop Biotechnology, International Service for the Acquisition of Agri-biotech Applications SEAsiaCenter (ISAAA), and AgBiotechNet 
September 27, 2002

In This Issue:

AFIC: Asians Favor GM Crops
NSF Puts $10.2M Into Corn Genetics 
IFIC Survey Points to Steady US Views on GM
Brazil Opens GM Food Analysis Lab 
CIRAD Says GMOS Could Help Developing Countries
Philippine Seminar on Social Acceptance of Biotech
Developing Countries Should Adopt Biotech, Says UN Panel
Key SAR Plant Defense Message Identified 
Changing Status of GM Crops in Europe? 
Bt Without the Markers

AFIC: ASIANS FAVOR GM CROPS

Most Asians have a positive attitude toward genetically modified (GM) foods. Furthermore, majority of consumers were positive and wanted to know more about the technology, and how it could improve the quality of everyday foods such as rice, fruit, vegetables, soybeans and corn. These were the results of a survey of the Asian Food Information Center (AFIC) through ISIS Research. The survey was conducted to get an accurate picture of what consumers in China, Thailand and the Philippines really think about GM foods.

The study had several key findings. Of the consumers surveyed, 66% believed that they would personally benefit from food biotechnology during the next five years. When they were asked to spontaneously name possible advantages and disadvantages to biotech foods, the number of benefits suggested was four times greater than the number of likely disadvantages. Sixty one percent (61%) of the respondents believed they had eaten GM foods recently and of those who believed they had eaten GM foods, 90% were satisfied with the situation and took no action to avoid it. Over 80% of those surveyed expressed willingness to try a snack food containing GM ingredients, if offered s sample.

AFIC conducted a similar survey in 1999 and the results of both surveys were consistent. Asian consumers are cautiously optimistic about the benefits that biotechnology could bring to their diet and would like more information about the issue.

For more information, go to http://www.afic.org/article.asp?Searchmethod=IndexPage&
ArticleID=266&PageName=default&CollectionType=5


IFIC SURVEY POINTS TO STEADY US VIEWS ON GM

The International Food Information Council (IFIC) says that its latest survey "U.S. Consumer Attitudes Toward Food Biotechnology" finds that opinions on food biotechnology are holding steady. Nearly three quarters (71% vs. 65% in 2001) of those surveyed said they would be likely to buy produce that had been enhanced through biotechnology for protection from insect damage and requiring fewer pesticide applications. In addition, more than half (54%) of American consumers would be likely to purchase the same produce if it had been enhanced to taste better or fresher, a number that has remained stable since October 1999. The survey was conducted for IFIC by Cogent Research in August 2002.

Most (61%) of consumers still expect to benefit from biotechnology over the next five years. Of those expecting benefits, 41% look to improved quality, taste, and variety, 39% cite the area of health and nutrition, and 20% expect biotech to reduce levels of chemicals and pesticides in food production.

About 72% of Americans stated they have read or heard information about the issue, and nearly half of consumers (48%) have heard about a new area of biotechnology called plant-made pharmaceuticals. However, as in previous surveys, the figures indicate that only a third of respondents believe there is food produced by biotechnology in US supermarkets, with a third saying this was not the case, and a further third indicating they didn't know.

The survey report says that a majority (59%) of Americans support the FDA's labeling policy which requires disclosure on a food label only if biotechnology introduces an allergen or substantially changes the food's nutritional content. Also, when asked what information they would like to see added to food labels, 78% of consumers said "nothing" and just 1% cited information related to biotech ingredients. However, this question was posed before biotech had been mentioned to the respondents.

The details of the survey are available at http://ific.org/relatives/17860.pdf 


CIRAD SAYS GMOS COULD HELP DEVELOPING COUNTRIES 

The French research organization CIRAD (Centre de Coopération Internationale en Recherche Agronomique pour le Développement) says that biotech could help in addressing key constraints in the developing world.

CIRAD says that biotechnology can provide methods to develop plants tolerant to dryness, salinity, harmful insects, or varieties having additional nutritional qualities". The organization said it would be irresponsible not to seriously explore the benefits and be unaware of the risks or how to take precautions.

CIRAD further said public research must evaluate the risks for food and the environment, and specify the conditions on how to use the results of this research. The governments and farmers of developing countries are entitled to this independent expertise vis-a-vis the multiple pressures of which they are the object.

CIRAD's genetic engineering work, which represents less than 2% of their work, focuses on rice, coffee, cotton and rubber, and various aspects of animal health. They have two principal objectives: to look further into the knowledge of the genetic operation of the tropical species in order to better manage and develop their genetic resources; and to study the application of transgenics to productions in the South when the potential interest justifies it.

The research organization's work on rice covers resistance to harmful insects, and tolerance to dryness and salinity. It is also investigating expression of traits in non-edible parts of the rice plant, and removal of marker genes such as antibiotic resistance. With cotton, durable resistance to insects would cut insecticide use greatly. Cotton seedlings with two different resistance genes are currently undergoing a contained trial in Brazil. It is also seeking to develop expression in the rubber-producing tissue of rubber plants. Transgenic coffee tree seedlings carrying an insect resistance gene are being assessed in the field in Guyana. 

CIRAD adds that, the first applications which are of interest to developing countries are now available. The organization also said that "genetic engineering is an extremely young discipline - the first transgenic plant was obtained only in 1983. It would be thus regrettable to condemn the products of tomorrow based on the limitations of present technology which is a result of yesterday's research".

For more information, see http://www.cirad.fr 


DEVELOPING COUNTRIES SHOULD ADOPT BIOTECH, SAYS UN PANEL 

Developing countries should consider adopting agricultural biotechnology, which can improve crop yields and safely provide more nutritious food at a lower cost, according to a panel meeting, 'Global Food Security and Sustainable Development: How to Improve Performance and Tap the Potential of Agricultural Biotechnology,' at the United Nations headquarters. 

In Southern Africa, especially Zambia, Zimbabwe and Malawi, more than 25 million people face starvation, yet some officials have been reluctant to accept food aid containing genetically modified (GM) food, they said. Sponsored by the Partnership to Cut Hunger and Poverty in Africa Program and the U.S. Mission to the United Nations, the panel featured scientists and economists.

Biotechnology has the potential to help Africa achieve higher yields, improve pest control and reduce dependence on chemical fertilizers, the panelists said. Appropriate use of biotechnology could lead to an agricultural revolution more dramatic than the "green revolution" of the last century, it was argued. The panelists said that at a time when a rational, international debate on the use of biotechnology is needed, discussion has become polarized. 

The issue of genetically modified food is critical not just for Africa but for other developing countries where more than half of the population lives in rural areas, said Peter McPherson, chairman of the Partnership to Cut Hunger and Poverty in Africa. 

"We know from history that if we're going to deal with poverty, let alone famine and other pressures it brings, you need to increase food production," McPherson said. "Certainly one of the options is biotechnology." McPherson said it is important for developing countries, especially those suffering drought and production problems, to know about recent developments in the field of agricultural biotechnology. 

Peter Gregory, director of biotechnology international programs at Cornell University, said agricultural biotechnology should be thought of as a complement, not a replacement, for traditional agricultural approaches. It is not something completely new, but a natural evolution from traditional agricultural techniques such as cross breeding, he said.

"I see biotechnology fitting specific needs in specific locations rather than a new panacea for everything," Gregory said. "It [biotechnology] employs the tools of modern genetics to enhance specific characteristics of crops and animals ... We expect to be able to get ... less expensive foods from GM crops, a broader array of more nutritious and safer foods and a lower overall cost of food because of higher productivity and reduced losses in the marketing chain...We are expecting more productive crops that are going to lead to higher and more stable rural incomes, more stable yields, reduced costs, reduced post-harvest losses", he added.

Panelists said the global debate on biotechnology is highly polarized while understanding of the facts is poor. They said the international community needs to develop a shared vision of the role of GM crops in sustainable agriculture, to generate and disseminate information from credible sources and to foster cooperation between developing and industrialized countries and between the private and public sectors.


CHANGING STATUS OF GM CROPS IN EUROPE?

Following a series of important European Union minister meetings in October, the informal ban on genetically modified (GM) crops may be lifted. A revised proposal will be presented, and if majority of the agriculture ministers are satisfied, the resistance from Denmark, Greece, France, Italy, Austria and Luxembourg will be dropped.

Meanwhile, the Department for International Development (DFID), the UK Government department responsible for promoting development and reducing poverty, was reported to have funded a 13.4 million pound program to create a new generation of GM animals, crops and drugs in developing countries. When confronted by groups opposed to agri-biotech, Secretary of State Clare Short said that her department was merely helping poor countries keep pace with GM crops.

And UK is not alone. An article by Brandon Mitchener which appeared in the Wall Street Journal Europe last September 20, 2002, reports that European GM research is being intended for use in other countries. Mitchener reports that around Europe, researchers at biotechnology companies, academic institutions and government laboratories are inventing new and improved beans, grapes, wheat and bananas that Europeans will probably never eat. But the research is intended for commercial applications in developing countries or the U.S., not the European Union, where food-labeling and other strict laws have all but banned bioengineered crops and foods.

The online articles are at http://www.euobserver.com/index.phtml?sid=9&aid=7650 and http://www.independent.co.uk/story.jsp?story=333367  


NSF PUTS $10.2 M INTO CORN GENOMICS

The US National Science Foundation (NSF) has awarded $10.2 million over two years to two projects for initial sequencing of the corn genome.

One project will be led by investigators at the Donald Danforth Center for Plant Sciences, St. Louis, who will collaborate with co-workers at the Institute for Genomic Research, Rockville, Maryland. The other project will be led by investigators at Rutgers University, who will collaborate with co-workers at the University of Arizona. The Rutgers University team includes international collaborators from France's Genoscope and Germany's Munich Information Center for Protein Sequences.

"This project will give us the first snapshot view of the sequence organization of the maize genome," said Mary Clutter, the Assistant Director for Biological Sciences at NSF. "It will pave the way for future whole genome sequencing efforts. It will also be the model for sequencing other large complex genomes."

The two projects will develop the tools needed to undertake large-scale sequencing of corn and will point the way to cost-effective sequencing of other large complex genomes. The resulting sequence data from both projects will be immediately deposited into public databases such as GenBank.

For more details, contact the Donald Danforth Plant Science Center at this email address: info@danforthcenter.org 


BRAZIL OPENS GM FOOD ANALYSIS LAB

The Brazilian research agency Embrapa Agroindústria de Alimentos has opened new facilities to assess the food safety of genetically modified organisms. It will also conduct analytical services for the food and drinks market in general. The new installations of the laboratories were recently inaugurated by the Minister of Agriculture, Cattle and Supply, Marcus Vinicius Pratini de Moraes at Avenue of Americas in Guaratiba, Rio de Janeiro.

EMBRAPA invested R$ 1.2 million (US$320,000) in the new facility. Visit http://www.embrapa.br for more information on the Brazilian research agency. 


PHILIPPINE SEMINAR ON SOCIAL ACCEPTANCE OF BIOTECH

A seminar entitled "Social Acceptance of Biotechnology-Myths and Facts" was held last 26 September 2002 at the Skytop, Hotel Intercontinental Manila, Makati City, Philippines. The seminar aimed to share and exchange latest information and developments on consumer attitudes concerning biotechnology products as well as provide an opportunity for consultation among stakeholders on educational programs that would promote understanding and appreciation of plants and foods derived from modern biotechnology. It featured three speakers representing different sectors.

The first was Atty. Jose Maria Ochave of the National Committee on Biosafety of the Philippines and Director, S and T Law Center. He reiterated his primary thesis that the major issues in agricultural biotechnology are ownership and access. Primarily, he recommended that for agricultural biotechnology to move forward in the Philippines, it must:

* Recognize agricultural biotech and biosafety as an indispensable strategic investment.
* Support publicly-funded research
* Encourage scientists to focus on relevant crops./plants and exploit available technology information
* Decrease the transaction costs for biotech research and development
* Engage the single-issue interest groups; and
* Provide greater public education.

The second speaker was Mr. Edwin Paraluman, a leader of the South Cotabato, Sarangani Province and General Santos City (SOCSARGEN) Provincial Farmers Action Council who shared his experiences on planting Bt corn. After witnessing the field trials of Bt corn in his province, he saw the benefits of the technology particularly in reducing pesticide use. However, he expressed frustration of not being able to avail of the technology yet.

Likewise, Dr. Thomas Jefferson Hoban IV, Professor of Sociology and Food Science of North Carolina State University, USA spoke on public concerns about biotechnology. He discussed several surveys which reveal that Asians have a positive attitude towards GM crops. To enhance market acceptance of agri-biotech in the market, Dr. Hoban suggests the following:

* Speed up the development of products with clear consumer benefits;
* Provide balanced information through a variety of credible sources;
* Improve and maintain confidence in science and the government regulatory system;
* Work to develop a cost-effective and efficient identity preservation system; and
* Address global policy challenges (e.g., the nonsense of traceability).

He said that "our key responsibility is to ensure that society has enough knowledge and foresight and continue to confirm safety before products are introduced into the environment and food supply".


KEY SAR PLANT DEFENSE MESSAGE IDENTIFIED

Researchers from the John Innes Centre (JIC) Norwich, University of Edinburgh, University of Toronto and the Noble Foundation have identified a key step in the systemic acquired resistance (SAR) pathway which could lead to new ways of engineering protection against plant disease.

DIR1 is involved in the transmission of a warning signal from plant cells infected by disease. The signal alerts cells, in areas remote from the infected site, that the plant is under attack and switches on defense mechanisms that prevent the disease establishing further infection sites. 


"As part of their defense against disease attack plants use internal communication systems to transmit warning signals around the plant", said Chris Lamb, JIC Director and leader of the research team at the JIC. "The protein we have discovered is essential to this warning system. It enables cells attacked by disease to transmit a signal that alerts other parts of the plant to the presence of infection. The signal stimulates cells, remote
from the attack site, to activate defenses that render them resistant to disease infection and this prevents the disease spreading through the plant".

The results of the research are presented in a paper "A putative lipid transfer protein involved in systemic resistance signalling in Arabidopsis" by Ana M. Maldonado, Peter Doerner, Richard A. Dixon, Chris J. Lamb and Robin K. Cameron which appears in Nature 419 (6905), 399-403.

Contact the John Innes Centre for more information at this email address: arabidopsis@bbsrc.ac.uk 


BT WITHOUT THE MARKERS

Efforts are now underway to produce second-generation transgenic plants that contain "clean events" without marker genes. As the name implies, marker genes are used to mark gene sequences when transferring desired traits to a host plant. They are used to provide a unique fingerprint of the DNA profile of an organism. Since marker genes are usually antibiotics, they have come under fire because of the possibility that they might confer antibiotic resistance to the host organisms and later on to humans.

Following extensive screening of over 3,000 initial transgenic plants, nine "clean events" were identified. Six contained the cry1B gene and three contained the cry1Ab gene. The nine transgenic lines were tested for Cry protein expression in root, leaf and whorl tissue by the International Maize and Wheat Improvement Center's (CIMMYT) Applied Biotechnology Center. Each event had a range of expression in the different tissues. Event 127 (cry1B) had the highest levels of Cry protein in the leaves and whorl with low levels in the roots.

The information is being gathered prior to further evaluation in Biosafety Greenhouses in Kenya. For further details go to http://www.independent.co.uk/story.jsp?story=333367

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