Crop Biotech Update

A weekly summary of world developments in agri-biotech for developing countries, produced by the Global Knowledge Center on Crop Biotechnology, International Service for the Acquisition of Agri-biotech Applications SEAsiaCenter (ISAAA), and AgBiotechNet

February 14, 2003

In This Issue:

Developing Countries Benefit More from GM Crops
NCGA and Divergence to Work on Nematode Control
North-South Partnership Needed to Build Up Biotech
Australians Track Transfer of Chloroplast DNA into Nucleus
Philippines Starts 'Super Rice' Program
Canada-Sweden Establishes Partnership for Forestry Genomics
Koreans Develop Multiple Stress-Tolerant Plant
France Proposes Tax Exemptions for Life Science Companies
Chen Says Biotech Important in China
Announcement

DEVELOPING COUNTRIES BENEFIT MORE FROM GM CROPS

Current existing genetically modified crops can have significant yield effects that are most likely to occur in the developing world. This is the conclusion of Matin Qaim and David Zilberman in an article entitled "Yield Effects of Genetically Modified Crops in Developing Countries," published in the February 7, 2003 issue of Science.

The economists from the University of Bonn in Germany, and University of California, respectively, argue that a major problem in developing countries like India is due to pest-related yield losses as a result of technical and economic constraints. An analysis of field trials of Bt cotton in India revealed that average yields of Bt hybrids exceeded those of non-Bt counterparts and popular checks by 80% and 87%, respectively. The yield gains, according to the economists, are largely due to the Bt gene itself. Bollworms, which are a major pest of cotton, have a high destructive capacity that is not well controlled in conventional cotton.

Bt hybrids were sprayed against bollworms three times less often than were non-Bt counterparts and popular checks. It was estimated that insecticide usage was reduced by 70%, amounting to pesticide savings worth about US$30 per hectare.

In addition, Qaim and Zilberman noted that pest-resistant GM crops are easy to manage at the farm level, and they could substantially reduce current gaps between attainable and actual yields, especially in smallholder farming systems. Comparing results with observations made also in Indonesia and South Africa, they hypothesized that on the basis of pest pressure and current crop protection, the biggest yield gains are expected in South and Southeast Asia and Sub-Saharan Africa.

The paper concludes that while there are more applications for agricultural biotechnology for developing countries beyond pest control, "GM crops developed so far can already have important impacts." They add that "although there is mounting evidence on the benefit side, the technological potentials are not widely acknowledged. Responsible risk management and balanced science communication are prerequisites for overcoming acceptance problems and ensuring sustainable use of GM crops."

The full paper is available online at http://www.sciencemag.org/cgi/reprint/299/5608/900.pdf


NORTH-SOUTH PARTNERSHIP NEEDED TO BUILD UP BIOTECH

"Governments from the North and the South need to enter into genuine partnerships to build up biotechnology capacity in the South and to tap the potential benefits of this technology for the poor and hungry of today and particularly tomorrow." This was one of the highlights of the paper by Prof. Eric Tollens of the Department of Agricultural and Environmental Economics at Katholieke Universiteit Leuven in Belgium.

Tollens pointed out that the South lacks the capacity to develop their own biotechnology applications, and to implement biosafety regulations and testing. To achieve the goals of food security and poverty alleviation (mostly in developing countries), collaboration and support is needed from the North to build up a biotechnology capacity in the South, which will include biosafety regulations and protocols. However, different environmental concerns between rich and poor countries can lead to different perspectives on the use of modern biotechnology. Other highlights of the paper include:

  • Another green revolution is needed to elevate global food production. This green revolution needs to be "doubly green," pertaining to increases in yield, and the enhancement of the environment. Biological technology (non-chemical) is also needed.
  • The next generation of transgenic crops should have definite consumer advantages (e.g., better nutritional value).
  • In developing countries, there is so much emphasis and focus on the risks and dangers of biotechnology that the potential of the technology is lost. Low-income people and countries should be empowered to make their own choices based on informed debate and their own risk-benefit calculations.
  • At present, the use of biotechnology is acceptable only for the development of vaccines, but not to genetically modify food for consumption. It is time to trust science and technology based on the science, and focus on the major issues.

For more details, email Prof. Eric Tollens at eric.tollens@agr.kuleuven.ac.be


PHILIPPINES STARTS 'SUPER RICE' PROGRAM

The Philippine's Department of Agriculture is set to implement its Hybrid Rice Commercialization Program (HRCP), the flagship program of President Gloria Arroyo's administration. Introduced as 'GMA Super Rice' in honor of the President, yield projections of the hybrid variety are expected to be up to 240 cavans of rice per hectare. This is almost triple the present average yield of 85 cavans for every hectare.

The program is expected to help make the country self-sufficient in rice at the soonest possible time. The Department of Agriculture and the Philippine Rice Research Institute (Philrice) recently signed a joint venture agreement for the propagation of the hybrid rice in an 8,000-hectare portion of the Iwahig Prison and Penal Farm (IPPF) in Puerto Princesa, Palawan.

PhilRice has targeted the development of about 8,000 hectares for the production of GMA super rice seed to be used in more than 300,000 hectares of rice fields nationwide and to attain the government's goal of self sufficiency in rice.


KOREANS DEVELOP MULTIPLE STRESS-TOLERANT PLANT

Korean researchers successfully developed transgenic plants with enhanced tolerance to multiple environmental stresses. "This technology can be applied to all plants at any time. It can also greatly contribute to improving the self-sufficiency of Korea", states Prof. Dae-Jin Yun of the Plant Molecular Biology and Biotechnology Research Center of Gyeongsang National University. The research team used the genetic system of Arabidopsis thaliana to determine the physiological role of nucleoside diphosphate kinase (NDPK) gene reactive oxygen species (ROS)- mediated signaling in plants.

Prof Dae-Jin Yun and colleagues investigated the influence of the expression of the NDPK gene in formation of ROS in Arabidopsis thaliana by over-expressing the NDPK gene. Over-expression of NDPK resulted in tolerance to cold, salt and H202 stresses. Their results suggested that NDPK plays a crucial role in the response to oxidative stress and they found out that the same gene is involved in regulation ROS regulation in plants. Generation of ROS in plants has been implicated in abiotic and biotic stress responses, in which the level of ROS is an important cellular regulator for stress response.

This research was partially supported by grant from the Plant Diversity Research Center of the 21st Century Frontier Research Program, Ministry of Science and Technology; Ministry of Agriculture and Forestry; Takara Biomedical Company, Korea and from the Biogreen 21 Program, Rural Development Administration, Korea.

The full research article is in the Proceedings of National Academy of Science, Volume 100, pages 358-363, 07 January 2003. It can be downloaded at http://www.pnas.org/
cgi/doi/10.1073/pnas.252641899


CHEN SAYS BIOTECH IMPORTANT IN CHINA

Zhangliang Chen, The President of China Agricultural University and Vice President of Beijing University, says agricultural biotechnology is an important new tool for improving yield and quality. The need for more science, especially biotechnology, to help feed the world's poor, was a strong theme in a forum of developing world science leaders in Christchurch, New Zealand. Some 1500 people attended the International Congress of Plant Pathology where Chen was a speaker.

Chen said China was feeding 22% of the world's population from 7% of the available land. However, while the population in China will not be stable until 2025, grain productivity had already stabilized in 1998. Research has concentrated on disease and insect control and licenses for six GM plant varieties were approved for commercialization in 1997-98.

Although there are more than 200 biotechnology laboratories in China, the Chinese government has been cautious. No new licenses had been approved since because of the concerns with GM in European Union countries.


NCGA AND DIVERGENCE TO WORK ON NEMATODE CONTROL

The National Corn Growers Association (NCGA) in the USA and Divergence, Inc. will do a joint research on the control of parasitic nematodes, including the identification of genes that might help provide resistance.

This research hopes to provide farmers with a safe method to protect plants from nematode pests. Current nematode control is accomplished by using chemicals that can have serious consequences to human and environmental health.

Divergence, a research and development company in St. Louis, USA, is developing nematicides, as well as nematode resistance plant genes that can be delivered as valuable traits in the seed. NCGA is a federation of state organizations, corn boards, councils and commissions that develops and implements policies and programs to help protect and advance corn producers' interests.

More information about the National Corn Growers Association at http://www.ncga.com


AUSTRALIANS TRACK TRANSFER OF CHLOROPLAST DNA INTO NUCLEUS

Choroplast DNA (cpDNA) moves into the nucleus at a detectable rate, but the differences in expression mechanisms is not an issue for transgenic plants created by inserting DNA into the chloroplast genome. This was pointed out by Jeremy Timmis and Chun Huang of the University of Adelaide and Michael Ayliffe at CSIRO Plant Industry in a paper published in Nature.

The researchers inserted a marker gene into the chloroplasts of tobacco plants and then looked for it in about 250,000 of their offspring. In about 1 in 16,000 of the seedlings, the gene had jumped from chloroplast to nucleus, and was being expressed in a heritable manner.

Timmis says "We have known that cpDNA is found in the nucleus for nearly 20 years but this is the first time the rate of transfer has been estimated experimentally." He added that researchers have not been doing similar experiments because "most people thought it would be an evolutionary process that would be just too rare to be measured in real time."

The finding has importance in the evolution of the plant genomes. Timmis clarifies that it is not possible to predict whether similar transfers are going on in other species. "Tobacco is rare in two respects: it is an allotetraploid and therefore may be more tolerant to such insertional events and it has a fairly large genome with quite a lot of "junk" repetitious DNA.

Contact Jeremy Timmis at his email address: jeremy.timmis@adelaide.edu.au


CANADA-SWEDEN ESTABLISHES PARTNERSHIP FOR FORESTRY GENOMICS

Aiming to help protect and maximize the value of Canada and Sweden's forestry resources, the University of British Columbia's Forestry Genomics Group, represented by Dr. Brian Ellis and colleagues, and the Swedish Tree Functional Genomics Consortium, headed by Dr. Goran Sandberg, recently announced the collaboration of their forestry genomics research projects.

This combined poplar genomics research aims to provide new sustainable strategies for breeding, nurturing and exploiting trees. This collaboration between the two countries is expected to deepen understanding of tree biology, particularly the genetic responses to stresses, pests and the environment.

The Sweden forestry project is partly funded by the Wallenberg Foundation, and the Swedish Foundation for Strategic Research (SSF). On the other hand, the Canadian research in poplar is in line with Canada's large-scale forestry project spearheaded by the University of British Columbia.

See the full news release at http://www.seedquest.com/News/releases/2003/february/5329.htm.


FRANCE PROPOSES TAX EXEMPTIONS FOR LIFE SCIENCE COMPANIES

French Prime Minister Jean-Pierre Raffarin and his ministerial colleagues for industry and research announced tax-cutting measures for research-based companies. If approved by the French parliament, French biotechnology companies would be exempt from paying "social costs" taxes, which amounts to a surcharge of 60% on salaries. They will also have 100% relief on corporate taxes.

Increases in share value would also be exempt from capital gains tax for both shareholders and other investors. This package is expected to be acceptable to the European Union (EU) industrial competition rules considering that it applies to all research-based companies.

However, the proposed package would include only those companies that spend more than 15% of turnover on research and development, and those that are less than ten years old. Of the total number of companies that will benefit from such an exemption, 15% are basically life sciences companies.

The full report is featured in Nature Biotechnology, Vol 21, February 2003 issue. It can also be downloaded at http://www.nature.com/naturebiotechnology.


ANNOUNCEMENT:

Conference on Biodiversity, Biotechnology and the Protection of Traditional Knowledge will be held at the Washington University School of Law, St. Louis, Missouri; April 4-6, 2003. Topics for discussion are: 1) the protection of biodiversity; 2) the protection and regulation of agricultural and plant biotechnology; and 3) the international intellectual property implications of both of the foregoing, particularly as they relate to the protection of traditional medicinal and agricultural knowledge.

For more information visit http://law.wustl.edu/centeris/upcomingevents/biodivsp02.html

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